BioMachines Nanoscopy Lab

The Weiss lab is an interdisciplinary group in the Department of Engineering Physics at Polytechnique Montreal. We develop tools that have broad applications ranging from probing the physical properties of biomaterials to biomedical diagnostics.

Le labo Weiss est un groupe interdisciplinaire du Département de génie physique de Polytechnique Montréal. Nous développons des outils qui ont de larges applications allant de l'étude des propriétés physiques des biomatériaux au diagnostic biomédical.

An animation reading Weiss Lab in bioluminescent fluid.

A bioluminescent media flowing through a microfluidic channel (Thanks Omer!)

Coming soon

Detecting directed motion and confinement in single-particle trajectories using hidden variables F Simon et al. BioRxiv (2024). doi.org/10.1101/2024.04.17.589798

- Characterization of trajectories -
- Operates on single tracks or populations of tracks -
- Classifies motion type and performs statistical likelihood tests -

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue. Andrews, Fu, & Toomey et al. BioRxiv (2024).
doi.org/10.1101/2024.02.17.580698

- Detection of α-synuclein oligomers -
- Colocalisation with cell markers -
- High-throughput pipeline -

The nuclear basket regulates the distribution and mobility of nuclear pore complexes in budding yeast. Zsok et al. BioRxiv. doi.org/10.1101/2023.09.28.558499

- Biophysical insight into the nuclear pore complex and nuclear basket proteins -
- Single-particle tracking -
- 3D particle trajectory simulation -