The Weiss lab is an interdisciplinary group in the Department of Engineering Physics at Polytechnique Montreal. We develop tools that have broad applications ranging from probing the physical properties of biomaterials to biomedical diagnostics.
Le labo Weiss est un groupe interdisciplinaire du Département de génie physique de Polytechnique Montréal. Nous développons des outils qui ont de larges applications allant de l'étude des propriétés physiques des biomatériaux au diagnostic biomédical.
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist. Zhang et al. BiorXiv (2024, Accepted @Optica). doi.org/10.1364/OPTICA.534148
- Localization in 4D (x, y, z, λ) at video framerates -
Fast analytical method to integrate multivariateGaussians over hidden variables. FC Simon, J Cardona, S Molesky, LE Weiss. HAL (2025).
hal.science/hal-04692487v2
- Statistical analysis framework -
- Trajectory analysis -
Monitoring DNA double-strand break repair in Saccharomyces cerevisiae at high throughput and high resolution. Y Shalev Ezra, A Saguy, G Levin, LE Weiss, O Alalouf, Y Shechtman. BioRxiv (2024).
doi.org/10.1101/2024.08.23.609327
- 3D imaging flow cytometry -
- PSF engineering -
Detecting directed motion and confinement in single-particle trajectories using hidden variables. F Simon et al. eLife (2024). doi.org/10.7554/eLife.99347.1
- Operates on single tracks or populations of tracks -
- Classifies motion type and performs statistical likelihood tests -
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue. Andrews, Fu, & Toomey et al. BioRxiv (2024).
doi.org/10.1101/2024.02.17.580698
- Co-localization -
- High-throughput pipeline -